Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction
نویسندگان
چکیده
Hospital No. 64, Russian University of People’s Friendship, Moscow, Russia; Orion Pharma, Research Center, Espoo, Finland; P. Stradin’s Research and Teaching Hospital, Latvian Medical Academy, Riga, Latvia; A.L. Myasnikov Institute of Cardiology, Cardiology Research Center, Moscow, Russia; Cardiology Clinic, Sklifosovsky Research Institute for Emergency Medicine, Moscow, Russia; Department of Gerontology and Geriatrics of Russian Medical Academy for Postgraduate Training, Moscow, Russia; Department of Clinical Pharmacology, University of Helsinki, Finland; Helsinki University Central Hospital, Cardiology Division, Helsinki, Finland; Academic Medical Center, University of Amsterdam, The Netherlands
منابع مشابه
The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia.
OBJECTIVES We assessed the effects of levosimendan on left ventricular (LV) function in patients with acute myocardial ischemia and after coronary angioplasty. BACKGROUND The calcium sensitizer levosimendan improves the function of myocardium in experimental stunning. METHODS Twenty-four patients with an acute coronary syndrome underwent angioplasty followed by double-blinded, randomized tr...
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PURPOSE OF REVIEW While patients with acute heart failure typically receive diuretics and vasodilators, contractile dysfunction and peripheral hypoperfusion also leads to a widespread use of inotropic agents despite the lack of evidence for efficacy or safety. Levosimendan, a calcium sensitizer and vasodilator, has been proposed to be superior to standard inotropes. In addition, further possibl...
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Technetium-99m-pyrophosphate (99mTc-PYP) has been used, in combination with thallium-201, to estimate the site and extent of myocardial infarcts. We report a case of acute myocardial infarction with severe coronary disease in which the distribution of 99mTc-PYP was extensive. A 78-year-old man presented with dyspnea, and a diagnosis of non-ST-segment elevation acute myocar...
متن کاملEuropean experience on the practical use of levosimendan in patients with acute heart failure syndromes.
The novel calcium sensitizer and ATP-dependent potassium channel opener levosimendan has been introduced for routine use in several European countries. Recent reports on clinical experience confirm the positive hemodynamic results and beneficial clinical effects described in the initial dose-finding and randomized comparative therapeutic trials in patients with severe low-output heart failure. ...
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Background: There is conflicting data about prognostic implication of electrocardiographic (ECG) left ventricular hypertrophy (LVH) in patients with first non- ST-segment elevation myocardial infarction (NSTEMI). We aimed to examine the association of left ventricular hypertrophy (LVH) on admission electrocardiogram with adverse outcomes in patients with NSTEMI. Methods: In the present study, ...
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